Product Details
| abID | ab79138 |
|---|---|
| Alternate Name | ADCP-2, ADABP, Dipeptidyl peptidase IV, DPP IV, T-cell activation antigen CD26, TP103, CD_antigen: CD26 |
| Gene Symbol | DPP4 |
| Gene ID | 1803 |
| Accession # | P27487 |
| Source | Baculovirus |
| Appearance | Sterile Filtered colorless solution |
| Physical Form Description | In 20 mM Tris-HCl buffer (pH 8.0) containing 100 mM NaCl, 1 mM EDTA, 10% glycerol |
| Molecular Weight | 85.4 kDa (737aa) (C-terminal His-tag) |
| Purity by SDS-PAGE | >95% |
| Endotoxin Level | < 1 EU per 1ug of protein (determined by LAL method) |
| Biological Activity | > 200 unit/mg |
| Amino Acid Sequence | aa 39-766 |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20ºC |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
DPP4, dipeptidyl peptidase-4 is a complex enzyme expressed on the surface of most cell types and is a serine exopeptidase that cleaves x-proline dipeptides from the N-terminus of polypeptides. DPP4 protein is associated with intracellular signal transduction, apoptosis and plays an important role in tumor biology. There are at least 63 substrates which can bind specifically to DPP4 enzyme including growth factors, chemokines, neuro peptides. Furthermore, DPP4 plays a major role in glucose metabolism by cleaving incretins such as glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). Recombinant human DPP4 protein was expressed with c-terminal His-tag in high-5 cells using baculovirus expression system and purified by using conventional chromatography techniques.
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