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DPP4/CD26, Human Recombinant

Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation.
Catalog #: P1572
SKU-Size Size Price Qty
P1572-10 10 μg
$105.00
P1572-50 50 μg
$325.00
More Sizes Get Quote

Product Details

Alternate Name ADCP-2, ADABP, Dipeptidyl peptidase IV, DPP IV, T-cell activation antigen CD26, TP103, CD_antigen: CD26
Gene Symbol DPP4
Gene ID 1803
Accession # P27487
Source Baculovirus
Appearance Sterile Filtered colorless solution
Physical Form Description In 20 mM Tris-HCl buffer (pH 8.0) containing 100 mM NaCl, 1 mM EDTA, 10% glycerol
Molecular Weight 85.4 kDa (737aa) (C-terminal His-tag)
Purity by SDS-PAGE >95%
Endotoxin Level < 1 EU per 1ug of protein (determined by LAL method)
Biological Activity > 200 unit/mg
Amino Acid Sequence aa 39-766
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

DPP4, dipeptidyl peptidase-4 is a complex enzyme expressed on the surface of most cell types and is a serine exopeptidase that cleaves x-proline dipeptides from the N-terminus of polypeptides. DPP4 protein is associated with intracellular signal transduction, apoptosis and plays an important role in tumor biology. There are at least 63 substrates which can bind specifically to DPP4 enzyme including growth factors, chemokines, neuro peptides. Furthermore, DPP4 plays a major role in glucose metabolism by cleaving incretins such as glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). Recombinant human DPP4 protein was expressed with c-terminal His-tag in high-5 cells using baculovirus expression system and purified by using conventional chromatography techniques.


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