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DPP4 Activity Fluorometric Assay Kit

based on 4 citations in multiple journalsDPP4 Activity Fluorometric Assay Kit44.1 4
Highly Sensitive Assay, HTS
Catalog #: K779

Product Details

Cat # +Size K779-100
Size 100 assays
Detection Method Fluorescence (Ex/Em 360/460 nm)
Species Reactivity Mammalian
Applications This kit detects DPP4 activity as low as 3 µU per well.
Kit Components • DPP4 Assay Buffer
• DPP4 Substrate (H-Gly-Pro-AMC)
• DPP4 Positive Control
• AMC Standard (10 μM)
• DPP4 Inhibitor (Sitagliptin)
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Dipeptidyl peptidase-4 (DPP4), also known as adenosine deaminase complexing protein 2 or CD26 (cluster of differentiation 26) is a protein that, in humans, is encoded by the DPP4 gene. The substrates of CD26/DPP4 are proline (or alanine) containing peptides and include growth factors, chemokines, neuropeptides, and vasoactive peptides. DPP4 plays a major role in glucose metabolism. It is responsible for the degradation of incretins such as GLP-1 and hence its inhibition by drugs such as Sitagliptin have been used for treatment of diabetes mellitus type 2. DPP4 also appears to work as a suppressor in the development of cancer and tumors. In BioVision’s DPP4 Activity Assay Kit, DPP4 cleaves a substrate to release a quenched fluorescent group, AMC (7-Amino-4-Methyl Coumarin), (Ex/Em = 360/460 nm). This assay is rapid, simple, sensitive, and reliable, as well as, suitable for high throughput activity screening of DPP4. This kit detects DPP4 activity as low as 3 µU per well.

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Yun Sok Lee, Hepatocyte-specific HIF-1α ablation improves obesity-induced glucose intolerance by reducing first-pass GLP-1 degradation. Sci Adv., July 2019;  31281892.
Mack et al., Spinal Myxopapillary Ependymomas Demonstrate a Warburg Phenotype. Clin. Cancer Res., Aug 2015; 21: 3750 - 3758.
Sanin et al., IL-10 Production in Macrophages Is Regulated by a TLR-Driven CREB-Mediated Mechanism That Is Linked to Genes Involved in Cell Metabolism. J. Immunol., Aug 2015; 195: 1218 - 1232.
Kanasaki et al., Linagliptin-Mediated DPP-4 Inhibition Ameliorates Kidney Fibrosis in Streptozotocin-Induced Diabetic Mice by Inhibiting Endothelial-to-Mesenchymal Transition in a Therapeutic Regimen. Diabetes, Jun 2014; 63: 2120 - 2131.
Nasib Ervinna et al., Anagliptin, a DPP-4 Inhibitor, Suppresses Proliferation of Vascular Smooth Muscles and Monocyte Inflammatory Reaction and Attenuates Atherosclerosis in Male apo E-Deficient Mice. Endocrinology, Mar 2013; 154: 1260 - 1270.
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