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DPP IV Inhibitor, NVP DPP 728

A potent DPP IV Inhibitor,
Catalog #: 1964
SKU-Size Size Price Qty
1964-1 1 mg
1964-5 5 mg
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Product Details

Alternate Name 6-[[2-[[2-(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethyl]amino]ethyl]amino-3-pyridinecarbononitrile Dihydrochloride
Appearance White solid
CAS # 247016-69-9
Molecular Formula C₁₅H₁₈N₆O.2HCl
Molecular Weight 371.27
Purity ≥98% by HPLC
Solubility DMSO (~100 mM) or EtOH (~ 100 mM)
InChi InChI=1S/C15H18N6O.2ClH/c16-8-12-3-4-14(20-10-12)19-6-5-18-11-15(22)21-7-1-2-13(21)9-17;;/h3-4,10,13,18H,1-2,5-7,11H2,(H,19,20);2*1H/t13-;;/m0../s1
PubChem CID 9799555
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A potent, selective, reversible, and slow binding dipeptidyl peptidase IV inhibitor (IC₅₀ = 14 nM). Displays >15,000 fold selectivity over DPP-II and a range of Proline-cleaving proteases. Displays anti-diabetic activity in vivo, improves glucose tolerance, increases glucagon-like peptide 1 (GLP-1) and insulin levels, and augments insulin secretion and GLUT-2 levels.

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