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A potent and selective pan-RAF inhibitor
Catalog #: B1288
SKU-Size Size Price Qty
B1288-5 5 mg
B1288-25 25 mg
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Product Details

Alternate Name 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea; LY3009120
Appearance Crystalline solid
CAS # 1454682-72-4 
Molecular Formula C₂₃H₂₉FN6O
Molecular Weight 424.52
Purity ≥98% by HPLC
Solubility DMSO
InChi InChI=1S/C23H29FN6O/c1-13-9-18(24)19(29-22(31)26-8-7-23(3,4)5)11-16(13)17-10-15-12-27-21(25-6)30-20(15)28-14(17)2/h9-12H,7-8H2,1-6H3,(H2,26,29,31)(H,25,27,28,30)
PubChem CID 71721540
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


DP-4978 is a potent and selective pan-RAF inhibitor with potential anticancer activity. DP-4978 displays activities against B-Raf or Ras mutant tumor cells. It binds to A-Raf, B-Raf and C-Raf isoforms with similar affinity in cells with activating mutations of B-Raf or K-Ras. 

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