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Doxifluridine

An oral prodrug of the antineoplastic agent 5-fluorouracil
Catalog #: B2650
SKU-Size Size Price Qty
B2650-50 50 mg
$85.00
B2650-250 250 mg
$295.00
More Sizes Get Quote

Product Details

Alternate Name Furtulon; 5'-Deoxy-5-fluorouridine; 5-fluoro-5'-deoxyuridine
Appearance White solid
CAS # 3094-09-5
Molecular Formula C₉H₁₁FN₂O₅
Molecular Weight 246.19
Purity ≥98%
Solubility >10 mg/ml DMSO, >20 mg/ml Water
SMILES CC1C(C(C(O1)N2C=C(C(=O)NC2=O)F)O)O
InChi InChI=1S/C9H11FN2O5/c1-3-5(13)6(14)8(17-3)12-2-4(10)7(15)11-9(12)16/h2-3,5-6,8,13-14H,1H3,(H,11,15,16)/t3-,5-,6-,8-/m1/s1
InChi Key ZWAOHEXOSAUJHY-ZIYNGMLESA-N
PubChem CID 18343
MDL Number MFCD00866530
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Doxifluridine is a fluoropyrimidine derivative that acts as an oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU) with antitumor activity. Doxifluridine, designed to circumvent the rapid degradation of 5-FU by dihydropyrimidine dehydrogenase in the gut wall, is converted into 5-FU in the presence of pyrimidine nucleoside phosphorylase. 5-FU interferes with DNA synthesis and subsequent cell division by reducing normal thymidine production and interferes with RNA transcription by competing with uridine triphosphate for incorporation into the RNA strand.


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