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Dovitinib lactate

A multitargeted RTK inhibitor
Catalog #: B1615

In stock

SKU-Size Size Price Qty
B1615-5 5 mg
$85.00
B1615-25 25 mg
$335.00

Product Details

Alternate Name Dovitinib lactate; TKI258; CHIR258; Dovitinib; TKI 258; CHIR 258; TKI-258; CHIR-258; 4-amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one 2-hydroxypropanoate hydrate; multitargeted receptor tyrosine kinase inhibitor
Appearance Solid
CAS # 915769-50-5
Molecular Formula C₂₄H₂₉FN₆O₅
Molecular Weight 500.53
Purity ≥98% by HPLC
Solubility DMSO
SMILES CC(C(=O)O)O.CN1CCN(CC1)C2=CC3=C(C=C2)NC(=C4C(=C5C(=NC4=O)C=CC=C5F)N)N3.O
InChi 1S/C21H21FN6O.C3H6O3.H2O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29;1-2(4)3(5)6;/h2-6,11,24-25H,7-10,23H2,1H3;2,4H,1H3,(H,5,6);1H2/b20-18-;;
InChi Key NOGSKCDVWBOZAQ-DJOSVPKASA-N
PubChem CID 16738710
MDL Number MFCD16038433
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Dovitinib (TKI258, CHIR258) is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGF-1R and HER2 in cell-free assays.


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