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Doripenem

A broad-spectrum β-lactam antibiotic
Catalog #: B2688
SKU-Size Size Price Qty
B2688-10 10 mg
$115.00
B2688-50 50 mg
$455.00
More Sizes Get Quote

Product Details

Alternate Name S 4661, 3-[[(3S,5S)-5S-[[(aminosulfonyl)amino]methyl]-3-pyrrolidinyl]thio]-6S-[(1R)-1-hydroxyethyl]-4R-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
Peptide Sequence N/A
Appearance White to yellow powder
CAS # 148016-81-3
Molecular Formula C₁₅H₂₄N₄O₆S₂
Molecular Weight 420.51
Purity ≥98%
Solubility ~ 20 mg/ml DMSO
SMILES O=C(O)C1=C(S[[email protected]@H]2CN[[email protected]](CNS(N)(=O)=O)C2)[[email protected]](C)[[email protected]@]([[email protected]@]3([H])[[email protected]](O)C)([H])N1C3=O
InChi InChI=1S/C15H24N4O6S2/c1-6-11-10(7(2)20)14(21)19(11)12(15(22)23)13(6)26-9-3-8(17-5-9)4-18-27(16,24)25/h6-11,17-18,20H,3-5H2,1-2H3,(H,22,23)(H2,16,24,25)/t6-,7-,8+,9+,10-,11-/m1/s1
InChi Key AVAACINZEOAHHE-VFZPANTDSA-N
PubChem CID 73303
MDL Number MFCD02092739
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Doripenem is a broad-spectrum β-lactam antibiotic. It is active against Gram-negative and Gram-positive bacteria, including S. aureus, S. pneumoniae, E. coli, and K. pneumoniae. Doripenem reduces the number of viable bacteria in mouse lung in a model of chronic P. aeruginosa respiratory tract infection when administered at a dose of 100 mg/kg per day. It inhibits bacterial cell wall synthesis by forming stable acyl enzymes with penicillin-binding proteins, thereby inactivating them.


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