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A potent p38 MAP kinase inhibitor
Catalog #: 1954
SKU-Size Size Price Qty
1954-5 5 mg
1954-25 25 mg
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Product Details

Alternate Name 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea; BIRB 796
Appearance White to off-white solid
CAS # 285983-48-4
Molecular Formula C₃₁H₃₇N₅O₃
Molecular Weight 527.66
Purity ≥98% by HPLC
Solubility DMSO (~50 mg/ml) or EtOH (~ 30 mg/ml)
InChi InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37)
PubChem CID 156422
MDL Number MFCD09752957
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cell-permeable. A potent protein kinase inhibitor with a >330-fold selectivity for p38 MAPK compared with 12 other protein kinases. In contrast to other p38 MAPK inhibitors (e.g., SB203580), doramapimod prevents both the kinetic activity and phosphorylation of p38 MAPK by binding to the ATP pocket as well as to a novel allosteric binding site on p38 MAPK.

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