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Product Details
| Alternate Name | 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;hydrochloride; Aricept; 2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride; E2020 |
|---|---|
| Appearance | White to off-white powder |
| CAS # | 120011-70-3 |
| Molecular Formula | C₂₄H₃₀ClNO₃ |
| Molecular Weight | 415.95 |
| Purity | ≥ 97% |
| Solubility | ~4 mg/ml in ethanol, ~20 mg/ml in water |
| SMILES | COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC.Cl |
| InChi | InChI=1S/C24H29NO3.ClH/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18;/h3-7,14-15,17,20H,8-13,16H2,1-2H3;1H |
| InChi Key | XWAIAVWHZJNZQQ-UHFFFAOYSA-N |
| PubChem CID | 5741 |
| MDL Number | MFCD00881312 |
| Handling | Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. |
| Storage Conditions | -20ºC |
| Shipping Conditions | RT |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Donepezil is a potent acetylcholinesterase (AChE) inhibitor with an IC₅₀ value of 5.7 nM. It produces a significant increase in acetylcholine content in rat cerebral cortex at a dose of 5 mg/kg (po). It is used for treating Alzheimer’s disease.
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