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Donepezil Hydrochloride

A potent acetylcholinesterase inhibitor
Catalog #: B3092
SKU-Size Size Price Qty
B3092-100 100 mg
$60.00
B3092-500 500 mg
$235.00
More Sizes Get Quote

Product Details

Alternate Name 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;hydrochloride; Aricept; 2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride; E2020
Appearance White to off-white powder
CAS # 120011-70-3
Molecular Formula C₂₄H₃₀ClNO₃
Molecular Weight 415.95
Purity ≥ 97%
Solubility ~4 mg/ml in ethanol, ~20 mg/ml in water
SMILES COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC.Cl
InChi InChI=1S/C24H29NO3.ClH/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18;/h3-7,14-15,17,20H,8-13,16H2,1-2H3;1H
InChi Key XWAIAVWHZJNZQQ-UHFFFAOYSA-N
PubChem CID 5741
MDL Number MFCD00881312
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

Donepezil is a potent acetylcholinesterase (AChE) inhibitor with an IC₅₀ value of 5.7 nM. It produces a significant increase in acetylcholine content in rat cerebral cortex at a dose of 5 mg/kg (po). It is used for treating Alzheimer’s disease.


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