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DMXAA

An apoptosis inducer and a mouse STING ligand
Catalog #: 2804

In stock

SKU-Size Size Price Qty
2804-5 5 mg
$155.00
2804-25 25 mg
$595.00
More Sizes Get Quote

Product Details

Alternate Name 2-(5,6-dimethyl-9-oxoxanthen-4-yl)acetic acid; Vadimezan; ASA404
Appearance White solid
CAS # 117570-53-3
Molecular Formula C₁₇H₁₄O₄
Molecular Weight 282.29
Purity ≥98% by HPLC
Solubility DMSO (>10 mg/ml)
SMILES CC1=C(C2=C(C=C1)C(=O)C3=C(O2)C(=CC=C3)CC(=O)O)C
InChi InChI=1S/C17H14O4/c1-9-6-7-13-15(20)12-5-3-4-11(8-14(18)19)17(12)21-16(13)10(9)2/h3-7H,8H2,1-2H3,(H,18,19)
InChi Key XGOYIMQSIKSOBS-UHFFFAOYSA-N
PubChem CID 123964
MDL Number MFCD00870555
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

DMXAA acts as a tumor vascular disrupting agent, inducing apoptosis in tumor vascular endothelium resulting in necrosis at the tumor core. It potently activates the TANK-binding kinase 1-interferon regulatory factor 3 signaling pathway in leukocytes, inducing type-I-interferon production. In addition, DMXAA significantly inhibits several kinases in endothelial cells, including the vascular endothelial growth factor (VEGF) receptors VEGFR1 and VEGFR2 (IC₅₀ = 119 and 11 µM, respectively). Recent studies have shown that DMXAA is a competitive agonist ligand for mouse.


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