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DMH-1

A selective BMP inhibitor
Catalog #: 9542
SKU-Size Size Price Qty
9542-5 5 mg
$125.00
9542-25 25 mg
$520.00
More Sizes Get Quote

Product Details

Alternate Name 4-[6-[4-(1-Methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline
Appearance Pale orange solid
CAS # 1206711-16-1
Molecular Formula C₂₄H₂₀N₄O
Molecular Weight 380.44
Purity ≥98% by HPLC
Solubility DMSO (>5 mg/ml)
SMILES CC(C)OC1=CC=C(C=C1)C2=CN3C(=C(C=N3)C4=CC=NC5=CC=CC=C45)N=C2
InChi InChI=1S/C24H20N4O/c1-16(2)29-19-9-7-17(8-10-19)18-13-26-24-22(14-27-28(24)15-18)20-11-12-25-23-6-4-3-5-21(20)23/h3-16H,1-2H3
InChi Key JMIFGARJSWXZSH-UHFFFAOYSA-N
PubChem CID 50997747
MDL Number MFCD18384953
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

DMH-1 is an analog of Dorsomorphin (Cat. No. 1686) that acts as a highly selective Bone morphogenetic protein (BMP) inhibitor. DMH-1 exclusively targets the BMP but not the VEGF pathway. Blocks BMP4-induced phosphorylation of Smads 1, 5 and 8 in HEK293 cells. Promotes neurogenesis in human induced pluripotent stem cells (iPSCs) when used in combination with SB-431542 (Cat. No. 1674).


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