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A sigma receptor agonist with neuroprotective activity
Catalog #: B3044
SKU-Size Size Price Qty
B3044-100 100 mg
B3044-500 500 mg
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Product Details

Alternate Name DTG; DOTG; 1,3-Di-o-tolylguanidine; 1,2-bis(2-methylphenyl)guanidine; {imino[(2-methylphenyl)amino]methyl}(2-methylphenyl)amine; 1,3-di-ortho-tolyl-guanidine
Appearance White to Off-White powder
CAS # 97-39-2
Molecular Formula C₁₅H₁₇N₃
Molecular Weight 239.32
Purity ≥98%
Solubility ~6 mg/ml in DMSO
InChi InChI=1S/C15H17N3/c1-11-7-3-5-9-13(11)17-15(16)18-14-10-6-4-8-12(14)2/h3-10H,1-2H3,(H3,16,17,18)
PubChem CID 7333
MDL Number MFCD00008513
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


Ditolylguanidine is a sigma receptor (σR) agonist with neuroprotective activity. It shows Kd values of 21.9 nM and 57.4 nM for σ2 and σ1 receptor respectively. Combined treatment with Ditolylguanidine (5 mg/kg) and memantine induces antidepressant-like effect in rats. Sigma receptor modulators are predicted to show activity against SARS-Cov-2, based on viral assay screens and interaction of the SARS-CoV-2 proteins Nsp6 and Orf9c with sigma receptors.

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