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Disulfiram

An alcohol dehydrogenase inhibitor
Catalog #: 2308
SKU-Size Size Price Qty
2308-50 50 mg
$55.00
2308-250 250 mg
$165.00
More Sizes Get Quote

Product Details

Alternate Name 1,1',1'',1'''-[disulfanediylbis(carbonothioylnitrilo)]tetraethane;Tetraethylthiuram disulfide; is(diethylthiocarbamyoyl)disulfide
Appearance Pale yellow solid
CAS # 97-77-8
Molecular Formula C₁₀H₂₀N₂S₄
Molecular Weight 296.54
Purity ≥97% by titration
Solubility DMSO (~ 6 mg/ml) or Ethanol (~ 30 mg/ml)
SMILES CCN(CC)C(=S)SSC(=S)N(CC)CC
InChi InChI=1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3
InChi Key AUZONCFQVSMFAP-UHFFFAOYSA-N
PubChem CID 3117
MDL Number MCFD00009048
Handling Protect from air and light
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

An alcohol dehydrogenase inhibitor used for the treatment of chronic alcoholism. Suppresses the invasive ability of osteosarcoma cells via the inhibition of MMP-2 and MMP-9 expression. Also inhibits JMJD2A, a 2-oxoglutarate dependent N(epsilon)-methyl lysine histone demethylase, by disruption of its Zn-binding site. Inhibits MERS-CoV and SARS-CoV PL protease in biochemical assays.


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Sana Sarvi, ALDH1 Bio-activates Nifuroxazide to Eradicate ALDHHigh Melanoma-Initiating Cells. Cell Chem Biol, Dec 2018; 30293938.
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