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DIRK1A/1B inhibitor AnnH31

A potent selective cell-permeable DYRK1A and DYRK1B inhibitor
Catalog #: B3287
SKU-Size Size Price Qty
B3287-100 100 µg
$115.00
B3287-500 500 µg
$425.00
More Sizes Get Quote

Product Details

Alternate Name AnnH31 2-(7-Methoxy-1-methyl-9H-pyrido[3,4-b]indol-9-yl)acetonitrile
Peptide Sequence N/A
Appearance Off-whitesolid
CAS # 241809-12-1
Molecular Formula C₁₅H₁₃N₃O
Molecular Weight 251.3
Purity ≥98% by HPLC
Solubility DMSO
SMILES CC1=NC=CC2=C1N(CC#N)C3=CC(OC)=CC=C3
InChi InChI=1S/C15H13N3O/c1-10-15-13(5-7-17-10)12-4-3-11(19-2)9-14(12)18(15)8-6-16/h3-5,7,9H,8H2,1-2H3
InChi Key FCFDJQKAPLIDTQ-UHFFFAOYSA-N
PubChem CID 9881447
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

DIRK1A/1B inhibitor AnnH31 is a potent selective cell-permeable DYRK1A (IC50 =81 nM) and DYRK1B inhibitor. Off-target inhibition of CLK1 and slightly DYRK2 and HIPK2. Displays minimal inhibitory effects on monoamine oxidase A (MAO A) (IC50=3.20 µg), with 40-fold selectivity for DYRK1A over MAO A. Dose-dependently reduces the phosphorylation of three known DYRK1A substrates (SF3B1, SEPT4 and tau) without negative effects on cell viability in cellular assays.


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