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Product Details
| Alternate Name | Diclofenamide 4,5-dichloro-1,3-benzenedisulfonamide |
|---|---|
| Appearance | Solid |
| CAS # | 120-97-8 |
| Molecular Formula | C₆H₆Cl₂N₂O₄S₂ |
| Molecular Weight | 305.16 |
| Purity | ≥98% |
| Solubility | >50 mg/ml DMSO |
| SMILES | C1=C(C=C(C(=C1S(=O)(=O)N)Cl)Cl)S(=O)(=O)N |
| InChi | InChI=1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14) |
| InChi Key | GJQPMPFPNINLKP-UHFFFAOYSA-N |
| PubChem CID | 3038 |
| MDL Number | MFCD00148948 |
| Handling | Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. |
| Storage Conditions | -20ºC |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Dichlorphenamide is a potent, orally bioavailable carbonic anhydrase (CA) inhibitor (Kis = 1.20, 38, 50, and 50 nM for the human CA isoforms CAI, CAII, CAIX, and CAXII, respectively). It lowers intraocular pressure in rabbits when 50 µl of a 10% solution is applied topically to the eye. Used in the treatment of glaucoma and primary periodic paralysis.
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