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Product Details
| Alternate Name | (9α,13α,14α)-3-methoxy-17-methyl-morphinan, hydrobromide monohydrate |
|---|---|
| Appearance | Crystalline solid |
| CAS # | 6700-34-1 |
| Molecular Formula | C₁₈H₂₅NO • HBr [H₂O] |
| Molecular Weight | 370.3 |
| Purity | ≥98% |
| Solubility | PBS, pH 7.2 (5 mg/ml), Ethanol or DMF (20 mg/ml), DMSO (12 mg/ml). Organic solvents should be purged in inert gas. Aqueous solutions should not be stored for >1 day. |
| SMILES | CN1[[email protected]@H]2[[email protected]@]3([H])CCCC[[email protected]@]3(CC1)C4=CC(OC)=CC=C4C2 |
| InChi | InChI=1S/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18+/m1/s1 |
| InChi Key | MKXZASYAUGDDCJ-NJAFHUGGSA-N |
| PubChem CID | 5462351 |
| MDL Number | MFCD02173901 |
| Handling | Do not take internally. Wear gloves and mask when handling! Avoid contact by all modes of exposure. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Dextromethorphan (DXM) is a morphinan with structural similarity to levorphanol, codeine, and morphine. DXM binds to and inhibits NMDA (IC50 = 0.55 μM) and nicotinic receptors (IC50s = 0.7-3.9 μM) and blocks receptor-gated and voltage-gated calcium channels (IC50 = 60 μM) and voltage-gated sodium channels (IC50 = 78 μM). It is a Cytochrome P450 2D6 substrate and it is converted into the active metabolite dextrorphan in the liver.
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