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Dextromethorphan (hydrobromide hydrate)

A Cytochrome P450 2D6 substrate
Catalog #: 2912
SKU-Size Size Price Qty
2912-50 50 mg
2912-100 100 mg
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Product Details

Alternate Name (9α,​13α,​14α)-​3-​methoxy-​17-​methyl-​morphinan,​ hydrobromide monohydrate
Appearance Crystalline solid
CAS # 6700-34-1
Molecular Formula C₁₈H₂₅NO • HBr [H₂O]
Molecular Weight 370.3
Purity ≥98%
Solubility PBS, pH 7.2 (5 mg/ml), Ethanol or DMF (20 mg/ml), DMSO (12 mg/ml). Organic solvents should be purged in inert gas. Aqueous solutions should not be stored for >1 day.
SMILES CN1[[email protected]@H]2[[email protected]@]3([H])CCCC[[email protected]@]3(CC1)C4=CC(OC)=CC=C4C2
InChi InChI=1S/C18H25NO/c1-19-10-9-18-8-4-3-5-15(18)17(19)11-13-6-7-14(20-2)12-16(13)18/h6-7,12,15,17H,3-5,8-11H2,1-2H3/t15-,17+,18+/m1/s1
PubChem CID 5462351
MDL Number MFCD02173901
Handling Do not take internally. Wear gloves and mask when handling! Avoid contact by all modes of exposure.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Dextromethorphan (DXM) is a morphinan with structural similarity to levorphanol, codeine, and morphine. DXM binds to and inhibits NMDA (IC50 = 0.55 μM) and nicotinic receptors (IC50s = 0.7-3.9 μM) and blocks receptor-gated and voltage-gated calcium channels (IC50 = 60 μM) and voltage-gated sodium channels (IC50 = 78 μM). It is a Cytochrome P450 2D6 substrate and it is converted into the active metabolite dextrorphan in the liver.

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