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Dexamethasone

based on 1 citations in multiple journalsDexamethasone14.1 4
An antiinflammatory agent
Catalog #: 1042
SKU-Size Size Price Qty
1042-1 1 ml
$85.00
1042-1G 1 g
$115.00
1042-10G 10 g
$530.00
More Sizes Get Quote

Product Details

Alternate Name 9α-Fluoro-16α-methylprednisolone, Prednisolone F, (11β,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione
Appearance Liquid
Formulation DMSO (10 mM)
CAS # 50-02-2
Molecular Formula C₂₂H₂₉FO₅
Molecular Weight 392.46
Purity >99% by TLC
SMILES CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C
InChi InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
InChi Key UREBDLICKHMUKA-CXSFZGCWSA-N
PubChem CID 5743
MDL Number MFCD00064136
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

An anti-inflammatory glucocorticoid. Inhibits the expression of the inducible but not the constitutive nitric oxide synthase in vascular endothelial cells (IC₅₀ = 5 nM). Enhances active cation transport in aortic smooth muscle cells by stimulating the Na+-K+ pump. Has anti-inflammatory and anti-rheumatic properties. Induces apoptosis in human thymocytes. In general, 500-1000 nM of dexamethasone is sufficient to induce apoptosis following a 6-hour incubation at 37°C


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Kudrin A. et al. (2006) J. Biol. Chrm. 281: 29641-29651.
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