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Destruxin B

A cyclic hexa-depsipeptide with insecticidal and anti-cancer properties
Catalog #: B2948
SKU-Size Size Price Qty
B2948-500 500 μg
B2948-1000 1000 μg
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Product Details

Alternate Name 16-butan-2-yl-10,11,14-trimethyl-3-(2-methylpropyl)-13-propan-2-yl-4-oxa-1,8,11,14,17-pentazabicyclo[17.3.0]docosane-2,5,9,12,15,18-hexone; SB 242536; NSC 236580
Appearance Solid
CAS # 2503-26-6
Molecular Formula C₃₀H₅₁N₅O₇
Molecular Weight 593.80
Purity ≥96%
Solubility 10 mg/ml in DMSO
InChi InChI=1S/C30H51N5O7/c1-10-19(6)24-29(40)34(9)25(18(4)5)30(41)33(8)20(7)26(37)31-14-13-23(36)42-22(16-17(2)3)28(39)35-15-11-12-21(35)27(38)32-24/h17-22,24-25H,10-16H2,1-9H3,(H,31,37)(H,32,38)
PubChem CID 428373
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Destruxin B is a cyclic hexadepsipeptide metabolite from the fungus Metarhizium anisopliae. It shows insecticidal and anti-cancer properties. It induces a concentration-dependent antiproliferative effect on lung adenocarcinoma A549 cells, with an IC₅₀ value of 4.9 μM. It induces apoptosis in the human non-small cell lung cancer cells A549 and H1299 cells via a Bcl-2 family-dependent mitochondrial pathway.

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