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Demethoxycurcumin

A curcumin analogue with anti-inflammatory and anti-proliferative properties
Catalog #: B2945
SKU-Size Size Price Qty
B2945-5 5 mg
$65.00
B2945-25 25 mg
$255.00
More Sizes Get Quote

Product Details

Alternate Name (1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione; Curcumin II; Desmethoxycurcumin; Monodemethoxycurcumin; Feruloyl-P-hydroxycinnnamoylmethane; feruloyl-p-coumaroylmethane; 1-(4-Hydroxystyryl)-3-(3-methoxy-4-hydroxystyryl)propanedial; (1E,4Z,6E)-5-Hydroxy-1-(4-hydroxy-3-methoxy-phenyl)-7-(4-hydroxy-phenyl)-hepta-1,4,6-trien-3-one
Appearance A crystalline solid
CAS # 24939-17-1, 22608-11-3
Molecular Formula C₂₀H₁₈O₅
Molecular Weight 338.35
Purity 95%
Solubility ~0.5 mg/ml in ethanol, ~10 mg/ml in DMSO and DMF
SMILES COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC=C(C=C2)O)O
InChi InChI=1S/C20H18O5/c1-25-20-12-15(6-11-19(20)24)5-10-18(23)13-17(22)9-4-14-2-7-16(21)8-3-14/h2-12,21,24H,13H2,1H3/b9-4+,10-5+
InChi Key HJTVQHVGMGKONQ-LUZURFALSA-N
PubChem CID 5469424
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

Demethoxycurcumin is a curcumin derivative with anti-inflammatory and anti-proliferative properties. It suppresses tumor necrosis factor (TNF)-induced nuclear factor-kappaB (NF-kappaB) activation in KBM-5 cells at 25 μM. It inhibits proliferation of different cell lines such as Jurkat, U937, KBM-5 and H1299 at 25 μM. It suppresses transcriptional coactivator p300 and inhibits the Wnt/beta-catenin pathway.


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