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A MEK1 inhibitor
Catalog #: B1690
SKU-Size Size Price Qty
B1690-5 5 mg
B1690-25 25 mg
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Product Details

Alternate Name GDC-0623; GDC0623; GDC 0623; 5-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide
Appearance Solid
CAS # 1168091-68-6
Molecular Formula C₁₆H₁₄FIN₄O₃
Molecular Weight 456.21
Purity >98%
Solubility DMSO
InChi InChI=1S/C16H14FIN4O3/c17-13-7-10(18)1-4-14(13)20-15-12(16(24)21-25-6-5-23)3-2-11-8-19-9-22(11)15/h1-4,7-9,20,23H,5-6H2,(H,21,24)
PubChem CID 42642654
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


GDC-0623 is a potent, ATP-uncompetitive inhibitor of MEK1 (Ki=0.13 nM, +ATP), and displays 6-fold weaker potency against HCT116 (KRAS (G13D), EC50=42 nM) versus A375 (BRAFV600E, EC50=7 nM).

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