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Product Details
| Alternate Name | FR180204; FR-180204; FR 180204; 5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-2H-pyrazolo[3,4-c]pyridazin-3-amine |
|---|---|
| Appearance | Solid |
| CAS # | 865362-74-9 |
| Molecular Formula | C₁₈H₁₃N₇ |
| Molecular Weight | 327.34 |
| Purity | >98% |
| Solubility | DMSO |
| SMILES | C1=CC=C(C=C1)C2=NN3C=CC=CC3=C2C4=CC5=C(NN=C5N=N4)N |
| InChi | InChI=1S/C18H13N7/c19-17-12-10-13(20-22-18(12)23-21-17)15-14-8-4-5-9-25(14)24-16(15)11-6-2-1-3-7-11/h1-10H,(H3,19,21,22,23) |
| InChi Key | XVECMUKVOMUNLE-UHFFFAOYSA-N |
| PubChem CID | 11493598 |
| MDL Number | MFCD14585805 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
FR180204 is a potent and selective ATP-competitive inhibitor of ERK1 and ERK2 with Ki value of 0.31 uM and 0.14 uM respectively; has IC50 values of 0.51 and 0.33 μM in enzymatic assays against ERK1 and ERK2, respectively.
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