Product Details
| Alternate Name | (7aS,13aS)-13,13a-Dihydro-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6′,5′-e]pyran-7(7aH)-one |
|---|---|
| Appearance | White to off-white solid |
| CAS # | 522-17-8 |
| Molecular Formula | C₂₃H₂₂O₆ |
| Molecular Weight | 394.42 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (~10 mg/ml) |
| SMILES | CC1(C=CC2=C(O1)C=CC3=C2OC4COC5=CC(=C(C=C5C4C3=O)OC)OC)C |
| InChi | InChI=1S/C23H22O6/c1-23(2)8-7-12-15(29-23)6-5-13-21(24)20-14-9-17(25-3)18(26-4)10-16(14)27-11-19(20)28-22(12)13/h5-10,19-20H,11H2,1-4H3/t19-,20+/m1/s1 |
| InChi Key | ORDAZKGHSNRHTD-UXHICEINSA-N |
| PubChem CID | 107935 |
| MDL Number | MFCD01740600 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Deguelin is a naturally occurring flavonoid that displays potent antiproliferative, antimetastatic, and apoptotic activity against several cancers both in vitro and in vivo. deguelin induces cell death by inhibiting several cell signaling pathways, such as PI3K-Akt, IKK-IκBα-NF-κB, AMPK-mTOR-survivin, and HIF-1α-VEGF.
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