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Decernotinib (VX-509)

A potent and selective JAK3 inhibitor
Catalog #: B1260
SKU-Size Size Price Qty
B1260-5 5 mg
$115.00
B1260-25 25 mg
$425.00
More Sizes Get Quote

Product Details

Alternate Name (R,Z)-2-((2-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-2-methyl-N-(2,2,2-trifluoroethyl)butanimidic acid
Appearance Crystaline solid
CAS # 944842-54-0
Molecular Formula C₁₈H₁₉F₃N₆O
Molecular Weight 392.38
Purity ≥98% by HPLC
Solubility DMSO (>20 mg/ml)
SMILES CCC(C)(C(=O)NCC(F)(F)F)NC1=NC(=NC=C1)C2=CNC3=C2C=CC=N3
InChi InChI=1S/C18H19F3N6O/c1-3-17(2,16(28)25-10-18(19,20)21)27-13-6-8-23-15(26-13)12-9-24-14-11(12)5-4-7-22-14/h4-9H,3,10H2,1-2H3,(H,22,24)(H,25,28)(H,23,26,27)/t17-/m1/s1
InChi Key ASUGUQWIHMTFJL-QGZVFWFLSA-N
PubChem CID 59422203
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Decernotinib (VX-509) is a potent and selective JAK3 inhibitor (Ki = 2 nM). it has been shown to dose dependently reduce proinflammatory responses in a rat collagen-induced arthritis model and a mouse model of oxazolone-induced delayed-type hypersensitivity.


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