A potent γ-secretase inhibitor
Catalog #: 2649 | abID:

Product Details

Alternate Name N-​[(1S)-​2-​[[(7S)-​6,​7-​dihydro-​5-​methyl-​6-​oxo-​5H-​dibenz[b,​d]azepin-​7-​yl]amino]-​1-​methyl-​2-​oxoethyl]-​3,​5-​difluoro-​benzeneacetamide
Appearance White to off-white solid
CAS # 209984-56-5
Molecular Formula C₂₆H₂₃F₂N₃O₃
Molecular Weight 463.48
Purity ≥98% by HPLC
Solubility DMSO (~ 35 mg/ml)
InChi InChI=1S/C26H23F2N3O3/c1-15(29-23(32)13-16-11-17(27)14-18(28)12-16)25(33)30-24-21-9-4-3-7-19(21)20-8-5-6-10-22(20)31(2)26(24)34/h3-12,14-15,24H,13H2,1-2H3,(H,29,32)(H,30,33)/t15-,24-/m0/s1
PubChem CID 11454028
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


DBZ is a potent γ-secretase inhibitor that blocks the cleavage of Notch into its active signaling effector, Notch intracellular domain, in human T cell lymphoma (SupT1) cells (IC₅₀ = 1.7 nM).

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