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Product Details
| Alternate Name | N², N⁴-Dibenzylquinazoline-2,4-diamine |
|---|---|
| Appearance | Colorless solid |
| CAS # | 177355-84-9 |
| Molecular Formula | C₂₂H₂₀N₄ |
| Molecular Weight | 340.42 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (~ 25 mg/ml) |
| SMILES | C1=CC=C(C=C1)CNC2=NC(=NC3=CC=CC=C32)NCC4=CC=CC=C4 |
| InChi | InChI=1S/C22H20N4/c1-3-9-17(10-4-1)15-23-21-19-13-7-8-14-20(19)25-22(26-21)24-16-18-11-5-2-6-12-18/h1-14H,15-16H2,(H2,23,24,25,26) |
| InChi Key | QAIMUUJJAJBPCL-UHFFFAOYSA-N |
| PubChem CID | 676352 |
| MDL Number | MFCD03691820 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Cell- permeable. A potent, selective, reversible, and ATP-competitive p97 inhibitor. DBeQ blocks both ubiquitin-dependent and autophagic protein clearance pathways and rapidly promotes executioner caspases -3 and -7.
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Tam et al., Intracellular sensing of complement C3 activates cell autonomous immunity. Science, Sep 2014; 345: 1256070.
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