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DBeQ

based on 1 citations in multiple journalsDBeQ14.1 4
A p97 inhibitor
Catalog #: 1858
SKU-Size Size Price Qty
1858-5 5 mg
$95.00
1858-25 25 mg
$365.00
More Sizes Get Quote

Product Details

Alternate Name N², N⁴-Dibenzylquinazoline-2,4-diamine
Appearance Colorless solid
CAS # 177355-84-9
Molecular Formula C₂₂H₂₀N₄
Molecular Weight 340.42
Purity ≥98% by HPLC
Solubility DMSO (~ 25 mg/ml)
SMILES C1=CC=C(C=C1)CNC2=NC(=NC3=CC=CC=C32)NCC4=CC=CC=C4
InChi InChI=1S/C22H20N4/c1-3-9-17(10-4-1)15-23-21-19-13-7-8-14-20(19)25-22(26-21)24-16-18-11-5-2-6-12-18/h1-14H,15-16H2,(H2,23,24,25,26)
InChi Key QAIMUUJJAJBPCL-UHFFFAOYSA-N
PubChem CID 676352
MDL Number MFCD03691820
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell- permeable. A potent, selective, reversible, and ATP-competitive p97 inhibitor. DBeQ blocks both ubiquitin-dependent and autophagic protein clearance pathways and rapidly promotes executioner caspases -3 and -7.


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Tam et al., Intracellular sensing of complement C3 activates cell autonomous immunity. Science, Sep 2014; 345: 1256070.
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