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DB07268

A potent JNK1 inhibitor
Catalog #: B1134
SKU-Size Size Price Qty
B1134-10 10 mg
$165.00
B1134-50 50 mg
$650.00
More Sizes Get Quote

Product Details

Alternate Name 2-[[2-(3-hydroxyanilino)pyrimidin-4-yl]amino]benzamide
Appearance Crystalline solid
CAS # 929007-72-7
Molecular Formula C₁₇H₁₅N₅O₂
Molecular Weight 321.34
Purity ≥98% by HPLC
Solubility DMSO (>3 mg/ml)
SMILES C1=CC=C(C(=C1)C(=O)N)NC2=NC(=NC=C2)NC3=CC(=CC=C3)O
InChi 1S/C17H15N5O2/c18-16(24)13-6-1-2-7-14(13)21-15-8-9-19-17(22-15)20-11-4-3-5-12(23)10-11/h1-10,23H,(H2,18,24)(H2,19,20,21,22)
InChi Key QHPKKGUGRGRSGA-UHFFFAOYSA-N
PubChem CID 16058637
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

DB07268 is a potent and selective JNK1 inhibitor with (IC₅₀ = 9 nM). DB07268 displays some degree of selectivity over quite a few kinases with the exceptions of CHK1, CK2, and PLK. Although DB07268 shows submicromolar potency against these three kinases, it still appears to exhibit at least 70- to 90-fold greater potency against JNK1 than CHK1, CK2, and PLK.


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