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Dasatinib (BMS-354825, Sprycel)

based on 1 citations in multiple journalsDasatinib (BMS-354825, Sprycel)14.1 4
A multi-kinase inhibitor selective to Bcr-Abl and Src
Catalog #: 1586

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SKU-Size Size Price Qty
1586-25 25 mg
1586-100 100 mg
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Product Details

Alternate Name BMS-354825, Sprycel
Appearance White to off-white solid
CAS # 302962-49-8
Molecular Formula C₂₂H₂₆ClN₇O₂S
Molecular Weight 488.01
Purity ≥99% by HPLC
Solubility DMSO (200 mg/ml)
InChi InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)
PubChem CID 3062316
MDL Number MFCD11046566
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


Dasatinib is a multi-kinase inhibitor with potent activity against BCR–ABL kinase (IC₅₀ <1 nM) and Src family kinases (IC₅₀ = 0.2–1.1 nM). Dasatinib also inhibits Lyn (IC₅₀ = 8.5 nM) and Src (IC₅₀ = 3.0 nM) kinase activities in vitro using 0.1 mg/mL poly (Glu4-Tyr) as the substrate.

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Lee, Yeon-Ju et al. (2016) Essential Role of Transglutaminase 2 in Vascular Endothelial Growth Factor–Induced Vascular Leakage in the Retina of Diabetic Mice Diabetes. 2016 Aug;65(8):2414-28.
Kanou, T. et. al. The Transmembrane Adaptor Cbp/PAG1 Controls the Malignant Potential of Human Non–Small Cell Lung Cancers That Have c-Src Upregulation. Mol. Cancer Res., Jan 2011; 9: 103 - 114.
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