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DASA-58

A selective pyruvate kinase M2 (PKM2) activator
Catalog #: B2163

In stock

SKU-Size Size Price Qty
B2163-1 1 mg
$75.00
B2163-5 5 mg
$295.00
More Sizes Get Quote

Product Details

Alternate Name 3-((4-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)sulfonyl)-1,4-diazepan-1-yl)sulfonyl)aniline; ML-203
Appearance Crystalline solid
CAS # 1203494-49-8
Molecular Formula C₁₉H₂₃N₃O₆S
Molecular Weight 453.53
Purity ≥98% by HPLC
Solubility DMSO (>50 mg/ml)
SMILES C1CN(CCN(C1)S(=O)(=O)C2=CC=CC(=C2)N)S(=O)(=O)C3=CC4=C(C=C3)OCCO4
InChi InChI=1S/C19H23N3O6S2/c20-15-3-1-4-16(13-15)29(23,24)21-7-2-8-22(10-9-21)30(25,26)17-5-6-18-19(14-17)28-12-11-27-18/h1,3-6,13-14H,2,7-12,20H2
InChi Key GMHIOMMKSMSRLY-UHFFFAOYSA-N
PubChem CID 44543605
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

DASA-58 is a selective activator of pyruvate kinase M2 (PKM2) (AC₅₀ = 38 nM). DASA-58 converts PKM2 to a constitutively active enzyme state that is resistant to inhibition by tyrosine-phosphorylated protein. In cancer, the altered glucose metabolism can be influenced by the regulatory properties of PKM2.


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