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A histone demethylase inhibitor

WARNING: This product can expose you to chemicals including Daminozide, which is [are] known to the State of California to cause cancer.  For more information go to
Catalog #: 2438
SKU-Size Size Price Qty
2438-100 100 mg
2438-500 500 mg
More Sizes Get Quote

Product Details

Alternate Name 1-​(2,​2-​dimethylhydrazide)-​butanedioic acid; Succinic acid mono(2,2-dimethylhydrazide)
Appearance White solid
CAS # 1596-84-5
Molecular Formula C₆H₁₂N₂O₃
Molecular Weight 160.17
Purity ≥95%
Solubility DMSO (~15 mg/ml) or EtOH (~ 3 mg/ml) or H₂O (~ 15 mg/ml)
InChi InChI=1S/C6H12N2O3/c1-8(2)7-5(9)3-4-6(10)11/h3-4H2,1-2H3,(H,7,9)(H,10,11)
PubChem CID 15331
MDL Number MFCD00002787
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A highly selective inhibitor of the human 2-oxoglutarate (JmjC) histone demethylases KDM2A, PHF8, and KDM7A with IC₅₀ values of 1.5, 0.55, and 2.1 μM, respectively. When tested for inhibition of other demethylase subfamily members (KDM3, KDM4, KDM5, KDM6) and other 2OG oxygenases (FIH, PHD2, BBOX1), daminozide was considerably less potent (IC₅₀’s > 100 μM).

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