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Product Details
| Alternate Name | 4-[4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-(2-pyridinyl) -1H-imidazol-2-yl]benzamide |
|---|---|
| Appearance | Off-white solid |
| CAS # | 301836-43-1 |
| Molecular Formula | C₂₃H₁₈N₄O₃ |
| Molecular Weight | 398.41 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (100 mM) |
| SMILES | C1COC2=C(O1)C=CC(=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5 |
| InChi | InChI=1S/C23H18N4O3/c24-22(28)14-4-6-15(7-5-14)23-26-20(21(27-23)17-3-1-2-10-25-17)16-8-9-18-19(13-16)30-12-11-29-18/h1-10,13H,11-12H2,(H2,24,28)(H,26,27) |
| InChi Key | DPDZHVCKYBCJHW-UHFFFAOYSA-N |
| PubChem CID | 6419753 |
| MDL Number | MFCD09037526 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
A cell-permeable, ATP-competitive inhibitor of casein kinase 1 (CK1) (IC₅₀ = 0.3 µM). Also inhibits ALK5 (IC₅₀ = 0.5 µM) and p38ɑMAP kinase (IC₅₀ = 12 µM). Displays selectivity over many other protein kinases.
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