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D4476

A casein kinase (CK) inhibitor
Catalog #: 1770
SKU-Size Size Price Qty
1770-1 1 mg
$80.00
1770-5 5 mg
$310.00
More Sizes Get Quote

Product Details

Alternate Name 4-[4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-(2-pyridinyl) -1H-imidazol-2-yl]benzamide
Appearance Off-white solid
CAS # 301836-43-1
Molecular Formula C₂₃H₁₈N₄O₃
Molecular Weight 398.41
Purity ≥98% by HPLC
Solubility DMSO (100 mM)
SMILES C1COC2=C(O1)C=CC(=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5
InChi InChI=1S/C23H18N4O3/c24-22(28)14-4-6-15(7-5-14)23-26-20(21(27-23)17-3-1-2-10-25-17)16-8-9-18-19(13-16)30-12-11-29-18/h1-10,13H,11-12H2,(H2,24,28)(H,26,27)
InChi Key DPDZHVCKYBCJHW-UHFFFAOYSA-N
PubChem CID 6419753
MDL Number MFCD09037526
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A cell-permeable, ATP-competitive inhibitor of casein kinase 1 (CK1) (IC₅₀ = 0.3 µM). Also inhibits ALK5 (IC₅₀ = 0.5 µM) and p38ɑMAP kinase (IC₅₀ = 12 µM). Displays selectivity over many other protein kinases.


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