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CZC-54252 hydrochloride

A potent leucine-rich repeat kinase 2 (LRRK2) inhibitor
Catalog #: 9567
SKU-Size Size Price Qty
9567-10 10 mg
$145.00
9567-50 50 mg
$575.00
More Sizes Get Quote

Product Details

Alternate Name N-[-[[5-Chloro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide hydrochloride
Appearance Yellow solid
CAS # 1191911-27-9
Molecular Formula C₂₂H₂₅ClN₆O₄S.HCl
Molecular Weight 541.45
Purity ≥98% by HPLC
Solubility DMSO (>40 mg/ml)
SMILES COC1=C(C=CC(=C1)N2CCOCC2)NC3=NC=C(C(=N3)NC4=CC=CC=C4NS(=O)(=O)C)Cl.Cl
InChi InChI=1S/C22H25ClN6O4S.ClH/c1-32-20-13-15(29-9-11-33-12-10-29)7-8-19(20)26-22-24-14-16(23)21(27-22)25-17-5-3-4-6-18(17)28-34(2,30)31;/h3-8,13-14,28H,9-12H2,1-2H3,(H2,24,25,26,27);1H
InChi Key KWCBHUPLQMUKAF-UHFFFAOYSA-N
PubChem CID 90488950
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

CZC-54252 is a potent inhibitor of leucine-rich repeat kinase 2 (LRRK2) (IC₅₀ values are 1.28 nM and 1.85 nM for wild-type and G2019S mutant forms of LRRK2 respectively). CZC-54252 attenuates neuronal injury induced by LRRK2-G2019S


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