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An inhibitor of LRRK2
Catalog #: B2941
SKU-Size Size Price Qty
B2941-5 5 mg
B2941-25 25 mg
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Product Details

Alternate Name N-[2-[[5-Fluoro-2-(2-methoxy-4-morpholin-4-ylanilino)pyrimidin-4-yl]amino]phenyl]methanesulfonamide; N-[2-[[5-fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-methanesulfonamide
Appearance A crystalline solid
CAS # 1191911-26-8
Molecular Formula C₂₂H₂₅FN₆O₄S
Molecular Weight 488.54
Purity >98%
Solubility ~10 mg/ml in DMSO and DMF
InChi InChI=1S/C22H25FN6O4S/c1-32-20-13-15(29-9-11-33-12-10-29)7-8-19(20)26-22-24-14-16(23)21(27-22)25-17-5-3-4-6-18(17)28-34(2,30)31/h3-8,13-14,28H,9-12H2,1-2H3,(H2,24,25,26,27)
PubChem CID 44252884
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


CZC-25146 is a potent inhibitor of Leucine-rich repeat kinase 2 (LRRK2) with an IC₅₀ of 4.76 nM. Mutations in LRRK2 are associated with Parkinson's disease. CZC-25146 attenuates LRRK2 G2019S mutant induced neuronal injury with EC₅₀ values of ~100 nM and 4 nM in primary rodent and human neurons respectively.

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