Product Details
| Antibody Target | Cytochrome p450 |
|---|---|
| Host | Rabbit |
| Antibody Type | Polyclonal |
| Isotype | Rabbit IgG |
| Immunogen | Synthetic peptide surrounding amino acid 405 of human Cytochrome p450 |
| Accession # | NP_000764 |
| Gene ID | 1571 |
| Appearance | Colorless liquid |
| Concentration | 0.5 mg/ml |
| Formulation | 100 µg (0.5 mg/ml) purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA and 0.01% thimerosal. |
| Purification | Affinity purified |
| Species Reactivity | Human, mouse, rat, dog |
| Application | Western blot |
| Application & Usage | Western blotting (0.5-4 µg/ml) .However, the optimal conditions should be determined individually. The antibody detects ~58kDa cytochrome P450 IIE1 from samples of human, mouse, rat and dog origins. |
| Handling | The antibody solution should be gently mixed before use. |
| Storage Conditions | -20 °C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Cytochrome P450 is mainly found in liver, and can metabolize a wide range of compounds such as organic solvents, acetaminophen, dimethylnitrosoamine and aliphatic alcohol, which have certain toxicological effects in humans. Ethanol-induced cytochrome P450 IIE1 is considered to be one of the major causes of oxidative stress in the liver following ethanol treatment.
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Liang, N. et. al. Steroidogenic Factor-1 Is Requipurple for TGF-β3-Mediated 17β-Estradiol Synthesis in Mouse Ovarian Granulosa Cells. Endocrinology, Aug 2011; 152: 3213 - 3225.
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