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Cytochrome P450 2D6, human recombinant

Human recombinant Cytochrome P450 2D6 from Sf9 cells can be used to screen human autoantibodies (autoimmune hepatitis), in ELISA assays, Western Blots and more
Catalog #: 7870
SKU-Size Size Price Qty
7870-5 5 μg
$185.00
7870-20 20 μg
$460.00
7870-1000 1 mg
$6,300.00
More Sizes Get Quote

Product Details

Alternate Name Cytochrome P450 2D6, CYPIID6, P450-DB1, Debrisoquine 4-hydroxylase, CYP2D6, CPD6, CYP2D, CYP2DL1, P450C2D, MGC120389, MGC120390, LKM1, liver/kidney microsomal antigen 1
Gene Symbol CYP2D6
Gene ID 1565
Accession # P10635
Source Sf9 Insect cells
Appearance Liquid
Physical Form Description Sterile filtered, 50 mM Potassium phosphate buffer pH 7.5, 15% glycerol, 1 mM DTT and 1% Triton X-100
Molecular Weight 55 kDa
Purity by SDS-PAGE Glycosylated, so purity ≥40%
Reconstitution Instructions In 50 mM Potassium phosphate buffer pH 7.5, 15% glycerol, 1 mM DTT and 1% Triton X-100
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Cytochrome P450 2D6 is a member of a family of microsomal enzymes (mono-oxygenases) present in the endoplasmic reticulum membrane, which detoxify xenobiotic compounds. Cytochrome P450 2D6 is the molecular target of autoantibodies against the "liver kidney microsomal antigen 1" (LKM 1) which has been classically studied by immunofluorescence microscopy. The presence of these autoantibodies is considered indicative of Autoimmune Hepatitis Type 2; LKM 1 antibodies have also been detected in patients with hepatitis C viral infection. The use of a purified recombinant Cytochrome P450 2D6 antigen allows the differentiation of autoimmune hepatitis from drug-induced hepatitis where transient autoantibodies to other P450 family members occur which cannot be differentiated by immunofluorescence techniques.


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