Cytochalasin D

A potent inhibitor of actin polymerization
Catalog #: B1176 | abID:

Product Details

Alternate Name Zygosporin A
Appearance White to off-white solid
CAS # 22144-77-0
Molecular Formula C₃₀H₃₇NO₆
Molecular Weight 507.6
Purity ≥95%
Solubility DMSO (~25 mg/ml)
InChi InChI=1S/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,36)27(17)34/h6-9,11-15,17-18,22-26,33,36H,3,10,16H2,1-2,4-5H3,(H,31,35)/b13-9+,15-14+/t17-,18+,22-,23-,24+,25-,26+,29+,30+/m0/s1
PubChem CID 5458428
MDL Number MFCD00077706
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cytochalasin D is a cell-permeable fungal toxin that acts as a potent inhibitor of actin polymerization; disrupts actin microfilaments; activates the p53-dependent pathways. It is about 10-fold more effective than Cytochalasin B and does not inhibit monosaccharide transport across cell membranes. Inactivates low conductance K⁺ channels. Modulates CD4 cross-linking in T-lymphocytes and increases intracellular Ca2+levels. Exhibits antitumor activity. Induces apoptosis.

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