Product Details
| Alternate Name | Zygosporin A |
|---|---|
| Appearance | White to off-white solid |
| CAS # | 22144-77-0 |
| Molecular Formula | C₃₀H₃₇NO₆ |
| Molecular Weight | 507.6 |
| Purity | ≥95% |
| Solubility | DMSO (~25 mg/ml) |
| SMILES | CC1CC=CC2C(C(=C)C(C3C2(C(C=CC(C1=O)(C)O)OC(=O)C)C(=O)NC3CC4=CC=CC=C4)C)O |
| InChi | InChI=1S/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,36)27(17)34/h6-9,11-15,17-18,22-26,33,36H,3,10,16H2,1-2,4-5H3,(H,31,35)/b13-9+,15-14+/t17-,18+,22-,23-,24+,25-,26+,29+,30+/m0/s1 |
| InChi Key | SDZRWUKZFQQKKV-JHADDHBZSA-N |
| PubChem CID | 5458428 |
| MDL Number | MFCD00077706 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Cytochalasin D is a cell-permeable fungal toxin that acts as a potent inhibitor of actin polymerization; disrupts actin microfilaments; activates the p53-dependent pathways. It is about 10-fold more effective than Cytochalasin B and does not inhibit monosaccharide transport across cell membranes. Inactivates low conductance K⁺ channels. Modulates CD4 cross-linking in T-lymphocytes and increases intracellular Ca2+levels. Exhibits antitumor activity. Induces apoptosis.
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