A potent JAK1 and JAK2 inhibitor
Catalog #: 2316 | abID:

Product Details

Alternate Name (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-l)-benzamide; CYT11387
Appearance Yellow to light orange solid
CAS # 1056634-68-4
Molecular Formula C₂₃H₂₂N₆O₂
Molecular Weight 414.46
Purity ≥98% by HPLC
Solubility DMSO (~80 mg/ml) or Ethanol (<1 mg/ml)
InChi InChI=1S/C23H22N6O2/c24-10-12-25-22(30)18-3-1-17(2-4-18)21-9-11-26-23(28-21)27-19-5-7-20(8-6-19)29-13-15-31-16-14-29/h1-9,11H,12-16H2,(H,25,30)(H,26,27,28)
PubChem CID 25062766
MDL Number MFCD16038899
Handling Protect from air and light
Storage Conditions -20 ̊C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Cyt387 is an ATP-competitive inhibitor of JAK1 and JAK2 with IC₅₀ values of 11 nM and 18 nM, respectively. Inhibits JAK3 at much higher concentrations (IC₅₀ = 155 nM).

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