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Cystathionine β Synthase, human recombinant

≥90% Pure Active Human recombinant Cystathionine β Synthase, an enzyme involved in sulphur amino acid metabolism
Catalog #: 7844
SKU-Size Size Price Qty
7844-100 100 μg
$295.00
7844-500 500 μg
$995.00
More Sizes Get Quote

Product Details

Alternate Name Beta-thionase, methylcysteine synthase, serine sulfhydrase
Gene Symbol CBS
Gene ID 102724560. 
Accession # P35520
Source E. coli
Appearance Liquid
Physical Form Description 0.5 mg/ml in 50 mM Tris, 100 mM NaCl, pH 8.0 and 20% glycerol
Molecular Weight 61.9 kDa (1-551 aa, NT His Tag)
Purity by SDS-PAGE ≥90%
Biological Activity 100 U/mg
Amino Acid Sequence 1-551 aa
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Cystathionine β-synthase (CBS; E.C. 4.2.1.22) is a PLP-dependent enzyme which plays a central role in sulfur amino acid metabolism in eukaryotes. CBS catalyzes condensation between serine and homocysteine to generate cystathionine, which is then further processed by cystathionine γ-lyase to yield cysteine. The gene encoding CBS is essentially linked to the genetic disorders of homocystinuria and Down syndrome. Homocystinuria is an autosomal recessive disease, characterized by high plasma levels of homocysteine, with clinical manifestations including mental retardation, thromboembolism and connective tissue defects. In addition, CBS also mediates synthesis of hydrogen sulfide by catalyzing condensation between cysteine and homocysteine. CBS is highly expressed in the nervous system, liver and kidney and is responsible for up to 95% of the H2S production in the brain.


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