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Cystamine dihydrochloride

A transglutaminase inhibitor
Catalog #: B2982
SKU-Size Size Price Qty
B2982-1G 1 g
$60.00
B2982-5G 5 g
$240.00
More Sizes Get Quote

Product Details

Alternate Name 2,2'-Disulfanediyldiethanamine dihydrochloride; Ethanamine, 2,2'-dithiobis-, dihydrochloride; Cystamin dihydrochloride; 2-(2-aminoethyldisulfanyl)ethanamine, dihydrochloride; 2,2'-Diaminodiethyl disulfide dihydrochloride
Appearance White powder
CAS # 56-17-7
Molecular Formula C₄H₁₄Cl₂N₂S₂
Molecular Weight 225.2
Purity 97%
Solubility ~5 mg/ml in DMSO, ~10 mg/ml in PBS, pH 7.2
SMILES C(CSSCCN)N.Cl.Cl
InChi InChI=1S/C4H12N2S2.2ClH/c5-1-3-7-8-4-2-6;;/h1-6H2;2*1H
InChi Key YUFRRMZSSPQMOS-UHFFFAOYSA-N
PubChem CID 5941
MDL Number MFCD00012905
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

Cystamine is an organic disulfide that inhibits transglutaminase (TGM2) with 44% inhibition observed at a concentration of 2.5 mM. It shows neuroprotective activity in a mouse model of Huntington’s disease. It has an anti-inflammatory effect and reduces severity of colitis in a rat model of inflammatory bowel disease.


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