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Cyclopamine

A hedgehog signaling inhibitor
Catalog #: 1578
$205.00

Product Details

Cat # +Size 1578-5
Size 5 mg
Alternate Name 11-deoxojervine
Appearance Off-white solid
CAS # 4449-51-8
Molecular Formula C₂₇H₄₁NO₂
Molecular Weight 411.62
Purity ≥99%
Solubility DMSO (4 mg/ml) and EtOH (5 mg/ml)
SMILES CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5CC4=C3C)C)O)C)NC1
InChi InChI=1S/C27H41NO2/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18,4)23(21)13-22(20)16(27)2/h5,15,17,19-21,23-25,28-29H,6-14H2,1-4H3/t15-,17+,19-,20-,21-,23-,24+,25-,26-,27-/m0/s1
InChi Key QASFUMOKHFSJGL-LAFRSMQTSA-N
PubChem CID 442972
MDL Number MFCD01735266
Handling Teratogen!
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cyclopamine blocks activation of the Hedgehog response pathway associated with mutations that either activate the proto-oncogene Smoothened (Smo) or inactivate the tumour suppressor Patched (Ptch) both of which encode multipass transmembrane proteins. Furthermore, it has been demonstrated that the inhibitory effect of cyclopamine results from its direct binding to the Smo heptahelical protein bundle


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