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Cyclopamine tartrate

A Hedgehog (Hh) signaling pathway inhibitor
Catalog #: 2518
SKU-Size Size Price Qty
2518-1 1 mg
$95.00
2518-5 5 mg
$375.00
More Sizes Get Quote

Product Details

Alternate Name (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-Octadecahydro-3',6',10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol tartrate; 11-Deoxojervine Tartrate; (3β,23β)-17,23-Epoxy- veratraman-3-ol Tartrate; 11-Deoxyjervine Tartrate; CycT
Appearance Crystalline solid
CAS # 1178510-81-0
Molecular Formula C₅₈H₈₈N₂O₁₀
Molecular Weight 973.32
Purity ≥98%
Solubility H₂O (~2 mg/ml)
SMILES O[[email protected]@H]1CC2=CC[[email protected]]3([H])[[email protected]]([[email protected]@]2(C)CC1)([H])CC4=C(C)[[email protected]@]5(O[[email protected]@]6([H])[[email protected]@]([[email protected]]5C)([H])NC[[email protected]@H](C)C6)CC[[email protected]@]34[H].[.C4H6O6]
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cyclopamine tartrate is a water-soluble derivative of the Hedgehog (Hh) signaling pathway inhibitor Cyclopamine (Cyc) (Cat. No.1578). Displays higher inhibitory activity for Hh signaling-dependent motor neuron differentiation than did Cyc (IC₀ = 50 nmol/L for CycT vs. 300 nmol/L for Cyc). CycT-treated mice shows tumor shrinkage and decreased expression of Hh target genes.


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