Product Details
| Alternate Name | (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-Octadecahydro-3',6',10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol tartrate; 11-Deoxojervine Tartrate; (3β,23β)-17,23-Epoxy- veratraman-3-ol Tartrate; 11-Deoxyjervine Tartrate; CycT |
|---|---|
| Appearance | Crystalline solid |
| CAS # | 1178510-81-0 |
| Molecular Formula | C₅₈H₈₈N₂O₁₀ |
| Molecular Weight | 973.32 |
| Purity | ≥98% |
| Solubility | H₂O (~2 mg/ml) |
| SMILES | O[C@@H]1CC2=CC[C@]3([H])[C@]([C@@]2(C)CC1)([H])CC4=C(C)[C@@]5(O[C@@]6([H])[C@@]([[email protected]]5C)([H])NC[C@@H](C)C6)CC[C@@]34[H].[.C4H6O6] |
| Handling | Protect from air and moisture |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Cyclopamine tartrate is a water-soluble derivative of the Hedgehog (Hh) signaling pathway inhibitor Cyclopamine (Cyc) (Cat. No.1578). Displays higher inhibitory activity for Hh signaling-dependent motor neuron differentiation than did Cyc (IC₀ = 50 nmol/L for CycT vs. 300 nmol/L for Cyc). CycT-treated mice shows tumor shrinkage and decreased expression of Hh target genes.
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