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Cyclopamine-KAAD

A Smoothened (Smo) antagonist
Catalog #: 1910
$135.00

Product Details

Cat # +Size 1910-50
Size 50 µg
Alternate Name 3-Keto-N-(aminoethyl-N’-aminocaproyldihydrocinnamoyl)cyclopamine; KAAD-cyclopamine
Appearance Pale yellow solid
CAS # 306387-90-6
Molecular Formula C₄₄H₆₃N₃O₄
Molecular Weight 697.99
Purity ≥80% by HPLC
Solubility DMSO or EtOH
SMILES CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(=O)CCC6(C5CC4=C3C)C)C)N(C1)CCNC(=O)CCCCCNC(=O)CCC7=CC=CC=C7
InChi InChI=1S/C44H63N3O4/c1-29-25-39-42(47(28-29)24-23-46-40(49)13-9-6-10-22-45-41(50)17-14-32-11-7-5-8-12-32)31(3)44(51-39)21-19-35-36-16-15-33-26-34(48)18-20-43(33,4)38(36)27-37(35)30(44)2/h5,7-8,11-12,15,29,31,35-36,38-39,42H,6,9-10,13-14,16-28H2,1-4H3,(H,45,50)(H,46,49)/t29?,31-,35?,36?,38?,39-,42?,43?,44?/m1/s1
InChi Key WDHRPWOAMDJICD-BWBMXWGBSA-N
PubChem CID 16760383
MDL Number MFCD03425585
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. A synthetic derivative of the natural product Cyclopamine (Cat. No. 1578-5) that acts as a specific inhibitor of Smoothened (Smo) and Sonic hedgehog (Shh) intracellular signaling (IC₅₀ = 20 nM in the Shh-LIGHT2 assay).


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