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Product Details
| Alternate Name | 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide, Actidione, Naramycin A |
|---|---|
| Appearance | • Liquid • Solid |
| Formulation | • 1041-1 (100 mM in DMSO) • 1041-1G (Solid) • 1041-5G (Solid) |
| CAS # | 66-81-9 |
| Molecular Formula | C₁₅H₂₃NO₄ |
| Molecular Weight | 281.35 |
| Purity | >95% |
| SMILES | CC1CC(C(=O)C(C1)C(CC2CC(=O)NC(=O)C2)O)C |
| InChi | InChI=1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1 |
| InChi Key | YPHMISFOHDHNIV-FSZOTQKASA-N |
| PubChem CID | 6197 |
| MDL Number | MFCD00082346 |
| Handling | Protect from light and moisture |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
A very active antibiotic against many yeasts and fungi. Inhibits protein synthesis in eukaryotes (but not in prokaryotes) by interfering with the translocation step. It inhibits chain initiation as well as chain elongation by acting on the 60S subunit of the eukaryote ribosome, interacting directly with enzyme translocase. Cycloheximide is used as an inhibitor to study cell-free protein biosynthesis in eukaryotes and also used to block ribosome-dependent in vivo polypeptide synthesis. It induces apoptosis in a variety of cells, but can also delay or inhibit apoptosis by other agents. It was shown to inhibit SARS-CoV and MERS-CoV in a high-throughput drug screen.
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Davydova et al., Identification and Characterization of a Novel Evolutionarily Conserved Lysine-specific Methyltransferase Targeting Eukaryotic Translation Elongation Factor 2 (eEF2). J. Biol. Chem., Oct 2014; 289: 30499 - 30510.
Hee-Jeong Jeong et al., Nonsense-Mediated mRNA Decay Factors, UPF1 and UPF3, Contribute to Plant Defense, Plant Cell Physiol., Dec 2011; 52: 2147 - 2156.
Muehlbauer, S. et al. Proteasome Inhibitors Prevent Caspase-1-Mediated Disease in Rodents Challenged with Anthrax Lethal Toxin. Am. J. Pathol., 2010; 177: 735-743.
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