A protein synthesis inhibitor

WARNING: This product can expose you to chemicals including Cycloheximide, which is [are] known to the State of California to cause birth defects or other reproductive harm.  For more information go to
Catalog #: 1041 | abID:

Product Details

Alternate Name 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide, Actidione, Naramycin A
Appearance • Liquid
• Solid
Formulation • 1041-1 (100 mM in DMSO)
• 1041-1G (Solid)
• 1041-5G (Solid)
CAS # 66-81-9
Molecular Formula C₁₅H₂₃NO₄
Molecular Weight 281.35
Purity >95%
InChi InChI=1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
PubChem CID 6197
MDL Number MFCD00082346
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A very active antibiotic against many yeasts and fungi. Inhibits protein synthesis in eukaryotes (but not in prokaryotes) by interfering with the translocation step. It inhibits chain initiation as well as chain elongation by acting on the 60S subunit of the eukaryote ribosome, interacting directly with enzyme translocase. Cycloheximide is used as an inhibitor to study cell-free protein biosynthesis in eukaryotes and also used to block ribosome-dependent in vivo polypeptide synthesis. It induces apoptosis in a variety of cells, but can also delay or inhibit apoptosis by other agents. It was shown to inhibit SARS-CoV and MERS-CoV in a high-throughput drug screen.

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Muehlbauer, S. et al. Proteasome Inhibitors Prevent Caspase-1-Mediated Disease in Rodents Challenged with Anthrax Lethal Toxin. Am. J. Pathol., 2010; 177: 735-743.
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