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Cycloheximide

based on 3 citations in multiple journalsCycloheximide34.1 4
A protein synthesis inhibitor
Catalog #: 1041
SKU-Size Size Price Qty
1041-1 1 ml
$85.00
1041-1G 1 g
$110.00
1041-5G 5 g
$215.00
More Sizes Get Quote

Product Details

Alternate Name 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide, Actidione, Naramycin A
Appearance • Liquid
• Solid
Formulation • 1041-1 (100 mM in DMSO)
• 1041-1G (Solid)
• 1041-5G (Solid)
CAS # 66-81-9
Molecular Formula C₁₅H₂₃NO₄
Molecular Weight 281.35
Purity >95%
SMILES CC1CC(C(=O)C(C1)C(CC2CC(=O)NC(=O)C2)O)C
InChi InChI=1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
InChi Key YPHMISFOHDHNIV-FSZOTQKASA-N
PubChem CID 6197
MDL Number MFCD00082346
Handling Protect from light and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A very active antibiotic against many yeasts and fungi. Inhibits protein synthesis in eukaryotes (but not in prokaryotes) by interfering with the translocation step. It inhibits chain initiation as well as chain elongation by acting on the 60S subunit of the eukaryote ribosome, interacting directly with enzyme translocase. Cycloheximide is used as an inhibitor to study cell-free protein biosynthesis in eukaryotes and also used to block ribosome-dependent in vivo polypeptide synthesis. It induces apoptosis in a variety of cells, but can also delay or inhibit apoptosis by other agents.


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Davydova et al., Identification and Characterization of a Novel Evolutionarily Conserved Lysine-specific Methyltransferase Targeting Eukaryotic Translation Elongation Factor 2 (eEF2). J. Biol. Chem., Oct 2014; 289: 30499 - 30510.
Hee-Jeong Jeong  et al., Nonsense-Mediated mRNA Decay Factors, UPF1 and UPF3, Contribute to Plant Defense, Plant Cell Physiol., Dec 2011; 52: 2147 - 2156.
Muehlbauer, S. et al. Proteasome Inhibitors Prevent Caspase-1-Mediated Disease in Rodents Challenged with Anthrax Lethal Toxin. Am. J. Pathol., 2010; 177: 735-743.
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