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CYC-116

A potent inhibitor of Aurora A and B
Catalog #: B1936

In stock

SKU-Size Size Price Qty
B1936-5 5 mg
$115.00
B1936-25 25 mg
$455.00

Product Details

Alternate Name 4-methyl-5-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]-1,3-thiazol-2-amine
Appearance Crystalline solid
CAS # 693228-63-6
Molecular Formula C₁₈H₂₀N₆OS
Molecular Weight 368.46
Purity ≥98% by HPLC
Solubility DMSO (~ 5 mg/ml)
SMILES CC1=C(SC(=N1)N)C2=NC(=NC=C2)NC3=CC=C(C=C3)N4CCOCC4
InChi InChI=1S/C18H20N6OS/c1-12-16(26-17(19)21-12)15-6-7-20-18(23-15)22-13-2-4-14(5-3-13)24-8-10-25-11-9-24/h2-7H,8-11H2,1H3,(H2,19,21)(H,20,22,23)
InChi Key GPSZYOIFQZPWEJ-UHFFFAOYSA-N
PubChem CID 6420138
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

CYC116 is a potent inhibitor of Aurora A and B with Ki value of 8 nM and 9.2 nM, respectively. It is significantly less potent against a panel of cyclin-dependent kinases and other related kinases, with the exception of Flt-3 (Ki = 44 nM). CYC-116 displays broad-spectrum antiproliferative activity against a panel of human cancer cell lines with a mean IC₅₀ value of 0.54 µM (range = 0.09 – 1.6 µM). 


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