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α-Cyano-4-hydroxycinnamic acid

A monocarboxylate transporter (MCT) inhibitor
Catalog #: B2162

In stock

SKU-Size Size Price Qty
B2162-500 500 mg
$55.00
B2162-1000 1 g
$75.00
More Sizes Get Quote

Product Details

Alternate Name α-CCA; 4-HCCA; CHCA; NSC173138; 4-CIN
Appearance Yellow solid
CAS # 28166-41-8
Molecular Formula C₁₀H₇NO₃
Molecular Weight 189.17
Purity ≥98% by HPLC
Solubility DMSO (10 mg/ml)
SMILES C1=CC(=CC=C1C=C(C#N)C(=O)O)O
InChi InChI=1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)/b8-5+
InChi Key AFVLVVWMAFSXCK-VMPITWQZSA-N
PubChem CID 5328791
MDL Number MFCD00004204
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

α-Cyano-4-hydroxycinnamate (4-CIN) is a monocarboxylate transporter (MCT) inhibitor. Displays antitumor and antiangiogenic activity in gliomas in vivo; decreases glycolytic metabolism, migration, and invasion in U251 cells. Also blocks lactate efflux from glioma cells and sensitizes cells to irradiation.


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