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Product Details
| Alternate Name | α-CCA; 4-HCCA; CHCA; NSC173138; 4-CIN |
|---|---|
| Appearance | Yellow solid |
| CAS # | 28166-41-8 |
| Molecular Formula | C₁₀H₇NO₃ |
| Molecular Weight | 189.17 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (10 mg/ml) |
| SMILES | C1=CC(=CC=C1C=C(C#N)C(=O)O)O |
| InChi | InChI=1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)/b8-5+ |
| InChi Key | AFVLVVWMAFSXCK-VMPITWQZSA-N |
| PubChem CID | 5328791 |
| MDL Number | MFCD00004204 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
α-Cyano-4-hydroxycinnamate (4-CIN) is a monocarboxylate transporter (MCT) inhibitor. Displays antitumor and antiangiogenic activity in gliomas in vivo; decreases glycolytic metabolism, migration, and invasion in U251 cells. Also blocks lactate efflux from glioma cells and sensitizes cells to irradiation.
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