CXCR4 Antibody

Catalog #: 5541 | abID:

Product Details

Antibody Target CXCR4
Alternate Name CXCR-4, CXCR4, CXCR 4,CXCR4 Polyclonal Antibody, Anti-CXCR4 Polyclonal antibody, CXCR4 antibody, Anti-CXCR4, CXCR, CD4, SDF, HIV-2, Fusin
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthetic peptide surrounding amino acid 18 of mouse CXCR4
Accession # P70658
Gene ID 12767
Appearance Colorless liquid
Concentration 0.5 mg/ml
Formulation Supplied in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.03% proclin
Purification Affinity purified
Species Reactivity Human, mouse, rat
Application Western blot
Application & Usage Western blot analysis (0.5-4 µg/ml). However, the optimal conditions should be determined individually. Blocking peptide (Cat.# 5541BP-50) is available separately.
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


CXCR4 (fusin) is a member in the seven-transmembrane domain G-protein-coupled chemokine receptor family. The full-length cDNA was isolated from a human spleen cDNA library. Its ligand is chemokine stroma-derived factor (SDF). CXCR4 has been shown to be the co-receptor for HIV-1 binding to CD4 throμgh the viral envelope glycoprotein gp120. In other cases, CXCR4 can function as the only receptor for the interaction of HIV-2 with CD4 and host cells. A mouse monoclonal antibody (12G5) to CXCR4 has been shown to inhibit HIV infectivity and HIV-induced syncytium.

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Tillmanns J et al. (2008) PNAS 105: 1668-1673.
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