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Anti-CXCR-7 Antibody

Polyclonal Antibody against AGTR5
Catalog #: A1066
$285.00

Product Details

Cat # +Size A1066-100
Size 100 µg
Antibody Target ACKR3
Alternate Name ACKR3; CXCR7; CMKOR1; GPR159; RDC1; C-X-C chemokine receptor type 7; CXC-R7; CXCR-7; Chemokine orphan receptor 1; G-protein coupled receptor 159; G-protein coupled receptor RDC1 homolog; RDC-1
Host Rabbit
Antibody Type Polyclonal
Isotype Rabbit IgG
Immunogen Synthesized peptide derived from the C-terminal region of human CXCR-7 (290-370aa)
Accession # P25106
Gene ID 57007
Appearance Colourless liquid
Concentration 1 mg/ml
Formulation 100 µg (1mg/ml) of antibody containing 50% glycerol, 0.5% BSA and 0.02% sodium azide
Species Reactivity Human, Mouse, rat, Monkey
Application WB, IHC, ELISA
Positive Control WB, IHC, ELISA
Application & Usage WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:20000;
Handling The antibody solution should be gently mixed before use.
Storage Conditions -20 °C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.


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