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CXCL14/BRAK, human recombinant

Chemoattractant for monocytes and dendritic cells
Catalog #: 4278
SKU-Size Size Price Qty
4278-10 10 μg
$175.00
4278-50 50 μg
$495.00
4278-1000 1 mg
$2,520.00
More Sizes Get Quote

Product Details

Alternate Name C-X-C motif chemokine 14 (Chemokine BRAK) (MIP-2G) (Small-inducible cytokine B14)
Gene Symbol CXCL14
Gene ID 9547
Accession # O95715
Source E. coli
Appearance Lyophilized protein
Physical Form Description Lyophilized from a 0.2 μm filtered solution of 20 mM Tris HCl and 1 M NaCl, pH 8.5.
Molecular Weight ~9.4 kDa
Purity by SDS-PAGE ≥95%
Purity by ≥95%
Endotoxin Level <0.1 ng/μg (1 IEU/μg)
Biological Activity The ED50 as determined by its ability to induce calcium flux of prostaglandin E2 treated THP1 human acute monocytic leukemia cells was 1.0-10.0 ng/ml.
Reconstitution Instructions Reconstitute the lyophilized recombinant human CXCL14 in sterile 18MΩ-cm H2O not less than 100 μg/ml. This can further be diluted to other aqueous buffers.
Amino Acid Sequence Recombinant Human CXCL14 produced in E. coli is a single, non-glycosylated, polypeptide chain containing 77 amino acids and having a molecular mass of 9.4 kDa. The sequence of the first five N-terminal amino acids was determined and was found to be Ser-Ly
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Human Chemokine (C-X-C motif) ligand 14(hCXCL14),also known as breast and kidney-expressed chemokine (BRAK), MIP-2 gamma, kidney-expressed chemokine (KEC), and B cell and monocyte-activating chemokine (BMAC), is a CXC chemokine constitutively expressed in certain normal tissues but is reduced or absent from many established tumor cell lines and human cancers. CXCL14 is known to be a chemo-attractant for monocyte and dendritic cells. CXCL14 inhibits angiogenesis and exhibits antimicrobial activities. Mature human and mouse CXCL14 differ by only 2 residues.


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