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CXCL10/IP-10/CRG-2, human recombinant

Chemoattractant for monocytes, T cells, NK cells, and dendritic cells
Catalog #: 4277
SKU-Size Size Price Qty
4277-10 10 μg
$125.00
4277-50 50 μg
$375.00
4277-1000 1 mg
$3,150.00
More Sizes Get Quote

Product Details

Alternate Name C-X-C motif chemokine 10 (10 kDa interferon gamma-induced protein) (Gamma-IP10) (IP-10) (Small-inducible cytokine B10) Cleaved into: CXCL10(1-73)
Gene Symbol CXCL10
Gene ID 3627
Accession # P02778
Source E. coli
Appearance Lyophilized protein
Physical Form Description Lyophilized from a 0.2 μm filtered solution of 20 mM PB and 150 mM NaCl, pH 7.0.
Molecular Weight 8.8 kDa
Purity by SDS-PAGE ≥95%
Purity by ≥95%
Endotoxin Level <0.1 ng/μg (1 IEU/μg)
Biological Activity The ED50 of rHu CXCL10 as determined by its ability to chemoattract human CXCR3 transfected BaF3 mouse proB cells was 0.02-0.06 μg/mL.
Reconstitution Instructions Dissolve in 1x PBS (It is not recommended to reconstitute to a final concentration less than 100 μg/ml). This can further be diluted to other aqueous buffers.
Amino Acid Sequence Recombinant human CXCL10/IP-10/CRG-2 is produced by E.coli transformed with a plasmid contains sequence (Val22-Pro98) of human CXCL10/IP-10/CRG-2 (Uniprot Entry: P02778) fused with a polyhistidine tag at the C-terminus. The sequence of the first five N-te
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Human Chemokine (C-X-C motif) ligand 10(CXCL10),also known as Interferon gamma-inducible protein-10 (IP-10), is a non-ELR chemokine secreted by various cell types including monocytes, endothelial cells and fibroblasts in response to IFN-γ. CXCL10 functions via chemokine receptor CXCR3. CXCL10 has been attributed to several roles, such as chemo-attraction for activated T-lymphocytes, inhibition of angiogenesis and antitumor activity.


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