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Product Details
| Alternate Name | C-X-C motif chemokine 10 (10 kDa interferon gamma-induced protein) (Gamma-IP10) (IP-10) (Small-inducible cytokine B10) Cleaved into: CXCL10(1-73) |
|---|---|
| Gene Symbol | CXCL10 |
| Gene ID | 3627 |
| Accession # | P02778 |
| Source | E. coli |
| Appearance | Lyophilized protein |
| Physical Form Description | Lyophilized from a 0.2 μm filtered solution of 20 mM PB and 150 mM NaCl, pH 7.0. |
| Molecular Weight | 8.8 kDa |
| Purity by SDS-PAGE | ≥95% |
| Purity by | ≥95% |
| Endotoxin Level | <0.1 ng/μg (1 IEU/μg) |
| Biological Activity | The ED50 of rHu CXCL10 as determined by its ability to chemoattract human CXCR3 transfected BaF3 mouse proB cells was 0.02-0.06 μg/mL. |
| Reconstitution Instructions | Dissolve in 1x PBS (It is not recommended to reconstitute to a final concentration less than 100 μg/ml). This can further be diluted to other aqueous buffers. |
| Amino Acid Sequence | Recombinant human CXCL10/IP-10/CRG-2 is produced by E.coli transformed with a plasmid contains sequence (Val22-Pro98) of human CXCL10/IP-10/CRG-2 (Uniprot Entry: P02778) fused with a polyhistidine tag at the C-terminus. The sequence of the first five N-te |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not to be used in humans |
Details
Human Chemokine (C-X-C motif) ligand 10(CXCL10),also known as Interferon gamma-inducible protein-10 (IP-10), is a non-ELR chemokine secreted by various cell types including monocytes, endothelial cells and fibroblasts in response to IFN-γ. CXCL10 functions via chemokine receptor CXCR3. CXCL10 has been attributed to several roles, such as chemo-attraction for activated T-lymphocytes, inhibition of angiogenesis and antitumor activity.
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