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An α(v) integrin inhibitor and known to suppress all 5 alpha V integrins
Catalog #: B1251

In stock

SKU-Size Size Price Qty
B1251-5 5 mg
B1251-25 25 mg
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Product Details

Alternate Name (3S)-N-[3-hydroxy-5-[(1,4,5,6-tetrahydro-5-hydroxy-2-pyrimidinyl)amino]benzoyl]glycyl-3-[3-bromo-5-(1,1-dimethylethyl)phenyl]-β-alanine
Appearance White Solid
CAS # 1564286-55-0
Molecular Formula C₂₆H₃₂BrN₅O₆ 
Molecular Weight 590.47
Purity ≥98% by HPLC
Solubility DMSO(>10 mg/ml)
InChi InChI=1S/C26H32BrN5O6/c1-26(2,3)16-4-14(5-17(27)8-16)21(10-23(36)37)32-22(35)13-28-24(38)15-6-18(9-19(33)7-15)31-25-29-11-20(34)12-30-25/h4-9,20-21,33-34H,10-13H2,1-3H3,(H,28,38)(H,32,35)(H,36,37)(H2,29,30,31)/t21-/m0/s1
PubChem CID 72949858
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


CWHM-12 a potent small molecule inhibitor of αV integrins with IC₅₀s of 1.8/0.8/1.5/0.2 nM for αvβ1/αvβ3/αvβ8. It displays less potency on αvβ5 (IC₅₀ = 61 nM) and on inhibition on αIIbβ3/α2β1/α10β1.

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